Welcome to MacGurn Lab!
We investigate fundamental mechanisms of membrane trafficking and protein degradation to advance understanding of aging and disease.
Lab Mission & Philosophy
We are focused on dissecting mechanisms of membrane trafficking and protein degradation. Such pathways play a fundamental role in the maintenance of healthy cells and tissues, and their breakdown contributes to the progression of disease and aging. Our long-term goal is to contribute new knowledge and understanding that informs novel strategies for the development of human therapeutics.
As a lab, we are deeply committed to:
-
- Contributing rigorous, reproducible research that adds value to society
- Training the next generation of scientists
- Serving the community through outreach activities that broadly promote STEM education
Lab News
Jason MacGurn Appointed to MRAD
Jason MacGurn has been appointed to the NIH MRAD Study Section with a term beginning in July 2026. As described on the NIH website: “Maximizing Investigators’...
Welcome Pedro Galhardo!
Pedro Henrique Ayres Galhardo, a first-year graduate student in Vanderbilt’s IGP program, has joined the MacGurn Lab for his thesis research. Pedro, a...
New Publication in Nature Cell Biology
Check out our recent collaborative study with the Burkewitz Lab, published in Nature Cell Biology (March, 2026). This study explores ER remodeling in aging...